∆QT Database

∆QTDb (delta QT Database) is a resource for exploring the effects of one or more drugs on the QT interval. It has been built from a deidentified subset of electrocardiogram and drug exposure data at Columbia University Medical Center.

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∆QTDb was developed by Tal Lorberbaum, Victor Nwankwo, and Nicholas Tatonetti. For any questions or comments about ∆QTDb please contact Dr. Tatonetti (nick.tatonetti{at}columbia.edu). ∆QTDb is currently being prepared for publication. For more information about the database, see our frequently asked questions.

Notes:

The QT interval on the electrocardiogram is a strong predictor of torsades de pointes, a potentially fatal arrhythmia. While much is known about individual drugs that can prolong the QT interval, less is known about the effects of multiple drugs taken at the same time.

Enter each drug you would like to investigate. For an example of a known QT-prolonging drug, try Amiodarone (Cordarone). For an example of a drug-drug interaction, try Ceftriaxone (Rocephin) + Lansoprazole (Prevacid).

Men and women are known to have different baseline QT intervals. Select whether you would like to see results for men, women, or both.

This histogram displays the frequency that a given change in QT interval is observed in ∆QTDb after drug exposure. In gray are the results observed across the entire database. In blue are the results observed for the selected drug(s). Mouse over a bin to see details for that subset of patients.